基于计算流体力学的TCAR手术仿真研究
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1.复旦大学 生物医学工程与技术创新学院,生物力学研究所;2.复旦大学附属中山医院 血管外科

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YU Long1,2, ZOU Chendong1, WANG Jiaxian3, GUO Daqiao3, WANG Shengzhang1
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1.Institute of Biomechanics, College of Biomedical Engineering, Fudan University;2.Department of Vascular Surgery, Zhongshan Hospital, Fudan University

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    摘要:

    目的 颈动脉狭窄是导致脑卒中的主要原因之一,临床上提出了一种新型的治疗方式:逆向血流保护下的经颈动脉支架成形术(TCAR)。TCAR的难点之一是引流导管阻力的设定,阻力太大会导致血液逆流不充分,阻力值太小可能会导致大脑缺血,因此有必要对阻力大小与脑血管主要动脉血流量的方向和大小之间的关系进行研究。方法 本研究基于计算流体力学方法,在后循环缺失病人的血管模型上进行TCAR手术仿真,调整导管中阻力柱内径,定量分析阻力柱内径对各主要动脉以及导管中血流量的影响。结果 未狭窄侧血流量对阻力柱内径变化并不敏感,狭窄侧颈内动脉流量会随阻力柱内径增大单调减少,狭窄侧颈外动脉流量则随阻力柱内径增大单调增长,导管流量随阻力柱内径增加而大幅度减少,越靠近狭窄发生处的血管血流量对于阻力柱内径变化越敏感。结论 本研究基于临床数据建立了具有患者特异性的TCAR数值仿真模型,通过计算流体力学仿真分析发现合理调整引流导管中的阻力可以改善狭窄侧脑组织供血,在保证颈内动脉血液逆流的同时降低脑组织缺血风险。

    Abstract:

    Objective Carotid artery stenosis is one of the major causes of stroke, and the mainstream solutions include endarterectomy and carotid stenting, but both of them have certain shortcomings. In this case, transcarotid ?a?rtery ?revascularization (TCAR) with reverse flow protection has been proposed clinically to treat carotid artery stenosis while theoretically circumventing the drawbacks of the original method. One of the difficulties of TCAR is the resistance valve, where too large a value of resistance can lead to insufficient reverse flow of blood, and too small a value of resistance can lead to cerebral ischemia. Methods In this study, based on the computational fluid dynamics method, we performed TCAR surgical simulation on a vascular model of a patient with posterior circulation loss, adjusted the inner diameter of the resistance column in the catheter, and quantitatively analyzed the effect of the inner diameter of the resistance column on the major arteries as well as the blood flow in the catheter. Results Blood flow on the unstented side was not sensitive to changes in resistance column ID, internal carotid artery flow on the stented side decreased monotonically with increasing resistance column ID, external carotid artery flow on the stented side increased monotonically with increasing resistance column ID, catheter flow decreased substantially with increasing resistance column ID, and the closer the stenosis occurred, the more sensitive blood flow was to changes in resistance column ID. Conclusions In this paper, a patient-specific numerical simulation model of TCAR was established based on clinical data, which can assess the intraoperative effects of TCAR to some extent and has potential clinical applications.

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  • 收稿日期:2025-07-07
  • 最后修改日期:2025-07-30
  • 录用日期:2025-07-31
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