Abstract: Objective This study investigates the influence of lattice structures on stress distribution across different functional regions of the plantar surface, aiming to mitigate localized stress concentrations and reduce the risk of foot injuries. Methods A subject-specific lattice shoe model was developed using lattice design methodology and coupled with a foot-lattice shoe finite element model. The physical lattice shoes were fabricated via 3D printing. Biomechanical data, including ground reaction forces and plantar pressure during static standing while wearing the shoes, were collected using experimental motion biomechanics techniques. Statistical analyses were conducted to validate the model. The effects of different lattice topologies on plantar loading and soft tissue surface stress were subsequently compared. Results The intraclass correlation coefficient (ICC) between the simulated and experimentally measured plantar pressures was 0.92, indicating a high level of agreement. Compared to the Body Centered Cubic (BCC) lattice structure, the IsoTruss (Iso) lattice showed the greatest stress reduction in the toe region (-66.90%), forefoot (-67.11%), and medial arch (-61.26%), while exhibiting the highest stress increase in the heel region (+70.33%). Conclusion The influence of different lattice topologies on plantar stress distribution is critical. The Iso lattice topology demonstrates significant pressure redistribution across various functional regions of the plantar surface, providing strong support in the heel area. In contrast, the BCC lattice topology exhibits superior cushioning performance in the heel region.