To investigate the impact of the mechanical properties of wrist vasculature and tissues under physiological conditions on oscillometric blood pressure measurement values. Methods Magnetic resonance imaging (MRI) was used to obtain cross-sectional images of the wrist when the cuff was pressurized. Ultrasound elastography was employed to measure the Young’s modulus of the skin, muscle, and tendon. The pressure envelope curve of the subjects was collected. The wrist cross-section was analyzed using imaging software to investigate the influence of different tissues on mechanical properties, and the characteristics of the oscillometric pressure envelope were compared. Simulations using Abaqus were conducted to investigate the effect of wrist tissue mechanical properties on oscillometric blood pressure measurement. Results At lower cuff pressures, significant changes in the wrist’s contour and cross-sectional area were observed; these variations diminished as cuff pressure increased. Young’s modulus of wrist tissues varied among volunteers and showed a correlation with the proportion of muscle tissue in the wrist cross-section. Simulations revealed that differences in tissue mechanical properties impact the peak amplitude of the oscillometric pressure envelope, consistent with trends observed in volunteers. Conclusion During cuff compression, the load and area strain of wrist tissues showed an obvious nonlinear relationship, in which skin, fat, and muscle all contributed to the area change. A higher average Young's modulus of the tissues corresponds to a smaller maximum amplitude of the oscillometric envelope.