灌流载荷作用下软骨支架的降解仿真研究
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1.天津理工大学机械工程学院;2.天津市口腔医院

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Numerical analysis on degradation of cartilage scaffold under perfusion loading
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    摘要:

    目的 通过数值模拟研究灌流力学刺激对支架降解的影响,实现对降解程度的预测。方法 基于灌流实验数据,利用Comsol建立流固耦合模型;采用Abaqus软件建立支架有限元模型。基于这两种模型,模拟并预测了支架的降解性能。结果(1)通过流固耦合仿真,发现7.89ml/min和15.79ml/min的灌流速度对支架产生的初始压强值成二倍关系,但沿着支架厚度方向从表面到底层,二者的压强值逐渐减小且数值接近;(2)将降解本构及有限元模型相结合实现了支架结构降解过程的动态仿真,获得的降解趋势数据与实验规律基本相符,在第56天β值可以达到0.643,与实验数据相比,模拟精度高于98%。结论(1)流固耦合仿真证明灌流速度越大支架受到的冲击压强越大,相同灌流速度下,支架表层的受力最大。(2)建立的降解本构及有限元模型可以预测支架的降解规律。

    Abstract:

    Objective The effect of irrigation mechanical stimulation on the degradation of scaffold was studied by numerical simulation to predict its degradation degree. Methods Based on the perfusion experimental data, the fluid-solid coupling model was established by Comsol. The finite element model of scaffold was established by Abaqus. Based on the models, the degradation performance of scaffold was obtained. Results (1) The fluid-solid coupling simulation shows that the initial pressure at the speed of 15.79mL /min is two-fold at 7.89mL /min. Along the thickness of scaffold from the surface to the bottom, the pressure values between the two velocity are gradually close to each other. (2) The degradation of scaffold structure can be simulated dynamically by combining the degradation constitutive model and finite element model. The degradation data obtained are consistent with the experimental data, and the β value can reach 0.643 on the 56th day. Compared with the experimental data, the simulation accuracy is higher than 98%. Conclusion (1) Fluid-solid coupling simulation shows that the larger the perfusion velocity is, the greater the pressure on the scaffold will be. Under the same perfusion velocity, the maximum force occurs on the surface of scaffold. (2) The degradation law of scaffold can be predicted by applying the degradation constitutive model and finite element model.

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  • 收稿日期:2021-04-19
  • 最后修改日期:2021-05-13
  • 录用日期:2021-05-14
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