基于Matlab的无创正压通气下呼吸道气阻与顺应性的在线测算方法研究
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1.湖南城市学院 机电工程学院;2.中国解放军总医院 呼吸内科;3.湖南明康中锦医疗科技发展有限公司长沙

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Matlab-Based Investigate the Algorithm in Online Monitoring the Respiratory Resistance and Compliance under Noninvasive Positive Airway Pressure Ventilation
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    摘要:

    目的 在无创正压通气下,避免对呼吸道内部进行操作、以及自主呼吸和漏气的干扰等,有效在线动态测算呼吸道气阻(resistance, R)和顺应性(compliance, C)。 方法 在呼气末气流为0时,控制呼气支持压跃降一个幅度为ΔP和时间宽度为Δt的负脉冲气压;在该负脉冲气压作用下,呼吸道出现短暂释放气流;通过获得Δt时间段的释放气流来计算R和C。另外,基于Matlab建立通气模型,模拟正常成人、ARDS患者和COPD患者的呼吸,进行仿真实验,获取仿真数据并计算验证。 结果 根据仿真数据计算得到正常成人、ARDS患者、COPD患者的R和C与实践赋值之间的误差分别为1.60%和-1.60%、-8.60和10%、-3.75%和4.00%。 结论 通过仿真实验,该算法具有可行性和适应性。本次仿真研究是进一步的研究与应用的重要基础,将有助于智能通气、比例辅助通气模式的研究与实现。

    Abstract:

    Objective under noninvasive positive pressure ventilation, in view of the inconvenient operations in the airway of human, and avoiding the interference of the spontaneous breathing and the necessary leakage flow, this paper devoted much attention on the method in getting the respiratory resistance (R) and compliance (C) on line. Method At the end of expiration, when the exhaled flow is 0, relative to the expiration positive airway pressure (EPAP), a step-dropped pressure is produced with the amplitude of (ΔP) and hold time of Δt. Under this dropped pressure, a discharge flow is generated from lung. In addition, a respiratory model was developed in MATLAB to simulate the breaths of normal adult, ARDS patient and COPD patient. With collecting the data of airflow in these simulation experiments, the corresponding R and C is calculated. Results The calculated R and C, for normal adult, ARDS patient, COPD patient, respectively deviate from the actual value with 1.60% and -1.60%, -8.60 and 10%, -3.75% and 4.00%. Conclusions The proposed algorithm is practicable and feasible for calculating the respiratory R and C. The implementation of this algorithm in simulation will be a strong basis for further researches and application. This algorithm is beneficial to study the intelligent ventilation and proportional assist ventilation in respirator.

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  • 收稿日期:2021-04-06
  • 最后修改日期:2021-05-30
  • 录用日期:2021-06-02
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