关节软骨微元流动电势的数值分析
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天津理工大学

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Numerical analysis of articular cartilage microelement streaming potential
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    摘要:

    摘要: 目的 为了解由间质液流动而产生的流动电势在关节软骨中的分布规律,获得一定的软骨电特性。方法 本文将流体控制方程与静电理论结合,建立软骨二维微元模型,通过有限元法计算在一定压力下微元内产生的稳态流动电势。结果 在长度为5μm处的关节软骨微孔隙模型中的流动电势约为38.4 μV,外压和Zeta电势对软骨模型的流动电势影响比较大,并且呈线性增长的关系。流动电势随离子浓度的增加而减小,但浓度的高、低对软骨流动电势影响有所不同,当离子数浓度较低时,流动电势对离子数浓度依赖较大;离子数浓度较高时,离子数浓度对流动电势的影响很小。结论 本研究结果为利用电流、电场、电磁场刺激等方法对软骨细胞的分化增殖、防治和治疗关节软骨疾病、组织工程化软骨的研制以及修复关节软骨损伤提供重要的理论依据。

    Abstract:

    Abstract: Objective To investigate the distribution of streaming potential generated by interstitial fluid flow in articular cartilage and to obtain the electrical characteristics of articular cartilage. Methods In this paper, the governing equation of fluid and electrostatic theory were combined to establish a two-dimensional microelement model of cartilage, and the steady flow potential generated in the microelement under certain pressure was calculated by finite element method. Results The streaming potential in the micropore model of articular cartilage with the length of 5μm was about 38.4μV. The effect of external pressure and Zeta potential on the streaming potential of articular cartilage model was significant and showed a linear increase relationship.The streaming potential decreased with the increase of ion concentration, but the high and low concentration had different effects on the streaming potential of cartilage. When the ion number concentration was low, the streaming potential was more dependent on the ion number concentration.When the ion number concentration is high, the effect of ion number concentration on the streaming potential is very small. Conclusion The results of this study provide important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of articular cartilage diseases, the development of tissue-engineered cartilage and the repair of articular cartilage injury by means of electric current, electric field and electromagnetic field stimulation.

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  • 收稿日期:2021-03-18
  • 最后修改日期:2021-04-23
  • 录用日期:2021-05-06
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