计算模拟血栓形成的研究进展
DOI:
作者:
作者单位:

首都医科大学附属安贞医院

作者简介:

通讯作者:

中图分类号:

基金项目:


Research progress in computational modeling of thrombosis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    血栓形成是机体受到某些物理和化学刺激后血液中发生血小板黏附聚集或血液凝固的过程。冠状动脉中的动脉血栓形成会限制流向心肌的血液从而导致心脏病的发作,另外血栓栓塞有可能引起严重的并发症甚至死亡。目前使用实验和计算模型了解血栓形成已成为广泛研究的主题。然而血小板活化与许多血液和组织因子一起参与该过程,各成分之间的化学相互作用是复杂的尤其是血流动力学可显着影响血栓的形成和生长。且由于机械和生化的高度复杂性,数学模型严重依赖于实验进行模型参数化,因此血栓形成和生长的计算建模非常具有挑战性,尽管存在这些挑战但计算模型的开发仍取得了很大进展。本文就目前血液血小板和血栓栓塞建模做一综述。

    Abstract:

    Thrombosis is the process of platelet adhesion and aggregation or blood coagulation in the blood after the body is subjected to certain physical and chemical stimuli. Arterial thrombosis in the coronary arteries restricts blood flow to the heart muscle and can lead to heart attacks. In addition, thromboembolism may cause serious complications and even death. At present, the use of experimental and computational models to understand thrombosis has become the subject of extensive research. However, platelet activation participates in this process together with many blood and tissue factors, and the chemical interactions between the components are complex, especially the hemodynamics can significantly affect the formation and growth of thrombus. In addition, due to the high complexity of machinery and biochemistry, mathematical models rely heavily on experiments for model parameterization. Therefore, computational modeling of thrombosis and growth is very challenging. Despite these challenges, the development of computational models has made great progress. . This article reviews the current modeling of blood platelets and thromboembolism.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2021-02-03
  • 最后修改日期:2021-04-16
  • 录用日期:2021-04-20
  • 在线发布日期:
  • 出版日期: