国家自然科学基金项目（11772073, 31700810, 11532004）
Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University
Lubricin is expressed among tissues in the musculoskeletal system, including articulate cartilage, tendon and synovium, which shows a close relationship to the structure and pathology of these tissues. Lubricin plays important roles in lubrication, anti-adhesion, prevention of proliferation and regulation of inflammation, which may facilitate the healing of impaired tissues in the musculoskeletal system. This article reviews the research progress on expression and regulation of lubricin as well as its structure and function in the wound repair of musculoskeletal system, which may provide research envidences for further research on the role of lubricin in musculoskeletal system with its ralated mechanisms and the application of lubricin in clinic.