Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine；Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology 在期刊界中查找 在百度中查找 在本站中查找
Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine；Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology 在期刊界中查找 在百度中查找 在本站中查找
Mechanical forces can induce aseptic inflammatory reactions in human tissues including periodontium, and promote the pyroptosis of immune cells and some non-immune cells such as periodontal ligament cells. Recent studies have revealed that Gasdermin-D (GSDMD) plays an indispensable role in inflammation as well as pyroptosis, while it remains unknown whether GSDMD participates in the mechanical force-induced inflammatory reaction and pyroptosis. The current progress in researches about the mechanical force-induced inflammatory reaction and the signaling pathways of pyroptosis in human tissues is reviewed.
